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鍏朵腑涓€椤圭爺绌剁敱鍒樻竻鍗庤棰樼粍棰嗚锛?strong>鎻ず浜嗚皟鎺у皬榧犵潯鐪犳椂闀跨殑鏍稿績鍒嗗瓙閫氳矾锛屽苟涓旀彁鍑轰簡杞綍璋冩帶鐫＄湢鐨勬柊鏈哄埗銆?/strong>
鎴戜滑鐭ラ亾锛岀潯鐪犳槸浜虹被鍜屼紬澶氬姩鐗╃敓鍛芥椿鍔ㄤ腑涓嶅彲鎴栫己鐨勪竴閮ㄥ垎锛屼絾鏈夎叮鐨勬槸锛屼笉鍚屽姩鐗╁鐫＄湢鐨勯渶姹傛湁鐫€宸ㄥぇ鐨勫樊寮傦細渚嬪闀块楣挎瘡澶╁彧闇€瑕佺潯2-5灏忔椂锛岃€岃€冩媺闇€瑕?8-22灏忔椂銆傛澶栵紝鍚岀鍔ㄧ墿涓笉鍚屼釜浣撶殑鐫＄湢鏃堕棿涔熶笉灏界浉鍚岋細澶氭暟浜烘瘡澶╅渶瑕?-8灏忔椂鐨勭潯鐪狅紝鑰屼竴浜涘ぉ鐢熺煭鐫＄湢鑰呭彧闇€瑕佺潯4-6灏忔椂灏辫兘淇濇寔姝ｅ父宸ヤ綔鐢熸椿銆?/p>
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鈻?strong>鎴愬勾灏忛紶鑴戠粏鑳炵壒寮傛€у熀鍥犺〃杈惧強鏁查櫎绯荤粺銆愬浘鐗囨潵婧愶細Wang, G. et al. Somatic Genetics Analysis of Sleep in Adult Mice. J. Neurosci. 42, 5617 (2022)銆?/strong>
鍩轰簬璇ョ郴缁燂紝鐮旂┒鑰呴鍏堝湪鎴愬勾灏忛紶涓暡闄や簡SIK3鐨?strong>涓婃父婵€閰禠KB1銆傝繖鏃讹紝灏忛紶鐨勭潯鐪犳椂闂翠笅闄嶄簡瓒呰繃3灏忔椂锛岃鏄?strong>LKB1鑳戒績杩涚潯鐪?/strong>銆傚悓鏃讹紝鐮旂┒鑰呰瀵熷埌鍦↙KB1鏁查櫎澶ц剳涓紝SIK3鐨勮嫃姘ㄩ吀娈嬪熀锛圱221锛夌７閰稿寲姘村钩涓嬮檷锛岃€屾惡甯︽ā鎷熺７閰稿寲鐨凾221E绐佸彉鍙互閮ㄥ垎鎻愬崌鐫＄湢鏃堕棿锛岃鏄?strong>LKB1-SIK3婵€閰剁骇鑱斾績杩涚潯鐪犮€?/strong>
涓庢涓€鑷寸殑鏄紝鐮旂┒鑰呬篃鍦↙KB1鏁查櫎澶ц剳涓瀵熷埌SIK3涓嬫父杞綍璋冭妭鍥犲瓙鈥斺€?strong>缁勮泲鐧藉幓涔欓叞鍖栭叾HDAC4/5鐨勪笣姘ㄩ吀娈嬪熀锛圫245锛夌７閰稿寲姘村钩涓嬮檷銆傝繘涓€姝ュ垎鏋愬彂鐜帮紝HDAC4/5浣嶄簬LKB1涓嬫父锛屾槸鎶戝埗鐫＄湢鐨勮浆褰曡皟鑺傚洜瀛愩€?/strong>
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