中国美业 | 长发 | 娱乐 | 健康 | 美妆 | 婚嫁 | 着装 | 手工 |
当前位置:中国美业 > 健康 > 科普 >
璇哄寰椾富娣遍櫡璁烘枃鍥剧墖閫犲亣婕╂丁锛屽悎鐞嗙殑鍥剧墖澶勭悊搴旂
更新时间:2022-11-16

褰撹濂栧緱涓昏鐖嗗嚭娑夊珜瀛︽湳涓嶇锛屼粬閫夋嫨浜嗘挙绋裤€備絾鐮旂┒浜哄憳涓嶅緱涓嶉潰涓翠竴涓毦棰橈細璁烘枃鍥剧墖鈥滅編鍖栤€濓紝杈圭晫鍦ㄥ摢锛?/p>

鎾版枃 | 灏忓彾

杩戝嚑涓湀锛屾牸鍒楁牸路璧涢棬鎵庯紙Gregg Semenza锛夆€斺€旇繖浣?019骞磋璐濆皵鐢熺悊瀛︽垨鍖诲濂栧緱涓婚夯鐑︿笉灏忋€?022骞?鏈?鏃ワ紝銆婄編鍥藉浗瀹剁瀛﹂櫌闄㈠垔銆嬶紙PNAS锛夊悓鏃跺垔鐧讳簡4绡囨挙绋垮0鏄庯紝鍧囨槸璧涢棬鎵庝綔涓洪€氳浣滆€呯殑缁嗚優鐢熺墿瀛﹁鏂囷紝鍘熷璁烘枃涓ょ瘒鍙戣〃浜?013骞?strong>[1, 2]銆佸叾浠栦袱绡囧垎鍒簬2009骞?strong>[3]鍜?014骞村彂琛?strong>[4]銆傚湪澹版槑涓紝鍖呮嫭閫氳浣滆€呭湪鍐呯殑鎵€鏈変汉鎵胯鍙兘瀛樺湪鍥剧墖/鏁版嵁澶嶅埗闂锛屼互鍙婂浘鐗囨嫾鎺ワ紝浣嗗悓鏃跺潥绉版墍鏈夌粨鏋滅湡瀹炲彲淇★紝閴翠簬鍥剧墖闂寮曞彂鐨勪笉渚匡紝鏈€缁堝喅瀹氫富鍔ㄦ挙绋裤€傝€屽叾涓袱绡囧悗缁忛獙璇佹€у疄楠屾洿鏂颁簡鍥剧墖[5, 6]锛屽彟涓€绡囧垯淇浜嗗浘鐗囬敊璇?strong>[7]锛屾渶缁堟洿鏂扮増鏈叏閮ㄥ彂琛ㄥ湪棰勫嵃鏈綉绔檅ioRxiv涓娿€?/p>

杩欏洓绡囨枃绔犻兘涓庤禌闂ㄦ墡鐨勮濂栨垚鏋溾€斺€旂己姘ц瀵煎洜瀛愮浉鍏筹紝鏃ㄥ湪鎺㈣鍖呮嫭鐧岀棁鍦ㄥ唴鐩稿叧鐤剧梾鐨勬満鍒跺拰娌荤枟鏂规銆傛牴鎹甈NAS鐨勫師濮嬭鏂囬〉闈㈢粺璁℃暟鎹紝鍥涚瘒鏂囩珷寮曠敤娆℃暟鎬诲叡瓒呰繃750娆°€傝縿浠婁负姝紝璧涢棬鎵庝釜浜哄苟鏈叕寮€鍙戣〃浠讳綍鍥炲簲銆?/p>

鏍煎垪鏍悸疯禌闂ㄦ墡锛圙regg Semenza锛?956-锛夊浘鐗囨潵婧愶細Nobel Media. Photo: A. Mahmoud

鎾ょ璁烘枃鍥剧墖閲嶅浣跨敤

鐢熺墿鍖诲棰嗗煙鏇濆嚭瀛︽湳涓嶇闂鍙哥┖瑙佹儻锛岃€岃繎骞存潵锛屽浘鐗囪瘹淇★紙image integrity锛夐棶棰樺挨涓虹獊鍑恒€備竴鏂归潰锛岄殢鐫€鎶€鏈墜娈电殑鏇存柊锛屽悇绉嶄慨鍥捐蒋浠舵帹闄堝嚭鏂帮紝鐮旂┒浜哄憳淇浘鏇村姞寰楀績搴旀墜銆傚綋鐒讹紝瀹屽叏鍚堣鐨勪慨鍥捐涓鸿兘鏇存竻鏅板湴鍛堢幇鐮旂┒缁撴灉锛屼緥濡傛彁楂樺浘鐗囧姣斿害鎴栬€呰壊褰╁钩琛★紝鍚屾椂杩樻柟渚夸綔鑰呬慨鏀瑰浘鐗囩紪杈戦敊璇€備絾涓嶅彲鍚﹁锛屼慨鍥惧伐鍏蜂篃鏄€犲亣鐨勨€滀竴鎶婂ソ鎵嬧€濓細澶嶅埗绮樿创鍙交鏉惧疄鐜颁竴鍥惧鐢紝photoshop淇浘澶ф硶锛堜範鎯О浣淧鍥撅級鏇存槸鏈€涓鸿療鐥呯殑閫犲亣濂楄矾銆傜敓鐗╁尰瀛︾晫渚濊禆鐨勮泲鐧藉厤鐤嵃杩癸紙Western Blot锛夊浘鍍忔妧鏈洿鏄鈥滈€犲亣鈥濋槾闇惧洟鍥㈢缃┿€傚洜姝わ紝闈㈠鎰堝彂涓ラ噸鐨勫浘鐗囬€犲亣瓒嬪娍锛屾棤璁烘湁蹇冭繕鏄棤鎰忥紝瀛︽湳鏈熷垔瀵圭鐮旇鏂囩殑鍥剧墖瀹℃牳鎰堝彂涓ユ牸锛岃€屼笖鐭ュ悕瀛︽湳鎵撳亣缃戠珯PeerPub涓婄鐮斾汉鍛樺郊姝や弗鏍肩洃鐫o紝涓€鏃﹀彂鐜板彲鐤戝浘鐗囷紝绔嬪埢鎵撳亣鎻彂锛屽笇鏈涗笉鏀捐繃浠讳綍鍙兘鐨勯€犲亣琛屼负銆?/p>

姝ゆ璧涢棬鎵庡洓绡囨挙绋胯鏂囨秹鍙婄殑鍥剧墖闂渚挎槸涓€涓吀鍨嬫渚嬨€?014骞村彂琛ㄧ殑璁烘枃Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells锛屼綔鑰呮寚鍑哄師鏂囧浘3E鍜屽浘5F锛堝浘1锛夈€佸浘6C涓庡浘8A鍙兘瀛樺湪閲嶅鏁版嵁锛堝浘2锛夈€傚鏋滀粩缁嗚瀵熷浘鐗囷紝鍑犱箮鍙互璁ゅ畾涓ゅ鍚勮嚜浣跨敤鐨勬槸鍚屼竴寮犲浘鐗囪繘琛屾嫾鎺ワ紝鑰屽畠浠垎鍒〃绀轰笉鍚岀殑鐮旂┒瀵硅薄銆?/p>

鍥? 涓ゅ紶涓嶅悓鐨勫浘娉?C鍜?A锛岄粍妗嗘墍绀哄浘鐗囧嚑涔庝竴妯′竴鏍凤紝鑰屽搴旂殑纭槸涓嶅悓鐨勫疄楠屽璞★紝鏉ユ簮锛歅ubPeer.com

鍥? 绾㈡柟妗嗕笌钃濇柟妗嗘爣鍑虹殑鍖哄煙鍥剧墖澶嶅埗銆佹嫾璐存槑鏄撅紝鏉ユ簮锛歅ubPeer.com

2009骞村彂琛ㄧ殑Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells璁烘枃涓紝PubPeer璇勮浜鸿涓哄師鏂囧浘2涓璙EGF鍚姩瀛愬湪20%O2鍜?%O2涓嬬浉浼煎害杩囬珮锛岀壒鍒槸缁忚繃姘村钩缈昏浆鍚庯紙瑙佷笅鍥?锛夛紝涔熸湁浜鸿涓哄共鑴嗗氨鏄暅鍍忕殑銆?/p>

鍥? 鍦≒ubPeer鐨勬墦鍋囪创涓婏紝闈㈠杩欏紶鍥炬敞锛屾湁鐮旂┒浜哄憳璐ㄧ枒姘村钩缈昏浆涔嬪悗鐩镐技搴︽湭鍏嶅お楂樹簡浜?鏉ユ簮锛歅ubPeer.com

鍙﹀浜?013骞村彂琛ㄧ殑涓ょ瘒Mutual antagonism between hypoxia-inducible factors 1伪 and 2伪 regulates oxygen sensing and cardio-respiratory homeostasis锛?鏈堬級鍜孒ypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells锛?鏈堬級鍚屾牱涔熸槸涓€鍥惧鐢ㄧ殑闂銆?鏈堝彂琛ㄧ殑杩欑瘒鏈€涓轰弗閲嶏紝浣滆€呭湪鎾ょ澹版槑涓槑纭寚鍑虹殑闂鍥剧墖楂樿揪10寮狅紝渚嬪锛屽浘1D涓€寮犲唴3澶勬暟鎹瓨鍦ㄩ噸澶嶉棶棰橈紱鍥?D鍜屽浘3B锛屽澶勬暟鎹€滄挒鍥锯€濈瓑绛夈€?/p>

2013骞?鏈堝彂琛ㄧ殑璁烘枃涓紝涓嶅悓棰滆壊鏂规鏍囧嚭涔嬪鍒嗗埆鏍囧嚭涓ゅ紶涓嶅悓鍥炬敞涓繃浜庡瘑闆嗙殑鐩镐技鐐广€傛潵婧愶細PubPeer.com

瀵逛簬涓婅堪绉嶇璐ㄧ枒锛屼綔鑰呯殑鍥涚瘒鎾ょ澹版槑閮戒竴涓€鍥炲簲锛屾牸寮忕粺涓€鏁撮綈锛氶鍏堟壙璁も€滃彲鑳藉瓨鍦ㄥ浘鐗?鏁版嵁閲嶅銆佸浘鐗囬敊璇€濆苟琛ㄧず姝夋剰锛岄殢鍚庡弽澶嶅己璋冧笉浼氬奖鍝嶇爺绌剁粨璁虹殑鐪熷疄鍙潬鎬э紝浣嗏€滈壌浜庝簤璁€犳垚鐨勪笉渚匡紝鍐冲畾涓诲姩鎾ょ鈥濄€傝嚦浜庝负浠€涔堜細澶嶅埗鏁版嵁銆佹槸鍚﹀瓨鍦ㄤ富瑙傝瀵肩瓑鍏蜂綋闂锛屼綔鑰呭苟娌℃湁缁欏嚭姝i潰鍥炲簲鍜岃В閲娿€?/p>

骞堕潪鍒濈姱

2022骞?鏈堢殑PNAS鎾ょ浜嬩欢骞堕潪棣栨璁╄禌闂ㄦ墡涓庡浘鐗囬€犲亣鑱旂郴璧锋潵銆備簨瀹炰笂锛岀涓€绡囪川鐤戣禌闂ㄦ墡璁烘枃鍥剧墖闂鐨勫笘瀛愭渶鏃╀簬2015骞村嚭鐜板湪PubPeer涓婏紝涓嶈繃褰撴椂骞舵湭寮曡捣浠讳綍鍏虫敞銆傞棶棰樼湡姝eぇ瑙勬ā鏆村彂瑕佷粠2020骞?鏈堝紑濮嬶紝涔熷氨鏄禌闂ㄦ墡鑾峰緱璇哄涓€骞翠箣鍚庯紝鐢ㄦ埛鍚嶄负Clair Francis鐨勫鏈墦鍋囦汉鍦ㄤ竴涓鏈堢殑鏃堕棿鍐咃紝涓€鍙f皵鎻彂浜?0澶氱瘒瀛樺湪鍥剧墖闂鐨勮鏂囷紝浜嬩欢璺ㄥ害浠?001骞磋嚦2018骞淬€?/p>

闄や簡渚嬪涓婅堪鏄剧ず鐨勪竴鏂囬噸澶嶇敤鍥鹃棶棰樺锛岃禌闂ㄦ墡鐨勮鏂囪繕娑夊強涓€鍥惧鏂囬噸澶嶄娇鐢紝鍗崇浉鍚屽浘鐗囧湪涓嶅悓鏂囩珷涓噸澶嶄娇鐢ㄣ€傜涓€绡囨挙绋垮師鏂?011骞村彂琛ㄤ簬銆婄敓鐗╁尰瀛︽湡鍒娿€嬶紙Biomedical Journal锛?strong>[10]锛岀粡鏈熷垔閲嶅锛岀紪杈戝彂鐜颁綔鑰呭皢鍏朵粬宸擦彂琛ㄧ殑璁烘枃鍥剧墖鐩存帴鎼繍鍒拌繖绡囪鏂囦腑銆?022骞?鏈堬紝銆婄檶鐥囩爺绌躲€嬶紙Cancer Research锛夋洿姝d簡涓€绡囪鏂囷紝骞堕拡瀵瑰彟涓€绡囧彂琛ㄥ叧娉ㄥ0鏄庯紝鍥犱负鍦ㄩ噸鏂拌皟鏌ョ殑杩囩▼涓紝缂栬緫鍙戠幇璁烘枃涓浜庝笉鍚屽疄楠岋紝浣滆€呬笉浠呮棤鎰忎腑鎻愪緵浜嗙浉鍚岀殑瀹為獙鏁版嵁缁撴灉锛岃€屼笖杩樼敤涓婁簡鏇存棭鏃跺€欏彂琛ㄧ殑璁烘枃鍥剧墖銆?/p>

杩樻湁灏戞暟鏂囩珷鍙兘娑夊強浼︾悊闂銆傛嵁缁熻锛屼簤璁鏂囦腑锛屾秹鍙娾€滀钩鑵虹檶鈥濄€佲€滃啝鐘跺姩鑴夊紓甯糕€濄€佲€滈珮琛€鍘嬧€濄€佲€滅孩缁嗚優澧炲鐥団€濈瓑鐤剧梾鐨勮鏂囪秴杩囦竴鍗娿€傛埅鑷充粖鏃ワ紝鍦≒ubPeer涓婅緭鍏ユ牸鍒楁牸路璧涢棬鎵庣殑濮撳悕浣滀负鎼滅储璇嶏紝鎬诲叡鍙互鐪嬪埌55绡囨墦鍋囧笘瀛愩€?strong>[11]

鏍规嵁銆婅嚜鐒躲€嬶紙Nature锛夋姤閬擄紝浠?011骞磋捣锛岃禌闂ㄦ墡浣滀负鍚堜綔浣滆€咃紝宸茬粡鏈?7绡囪鏂囨槑纭挙绋挎垨淇銆佹垨鏈熷垔鍙戣〃鍏冲垏澹版槑锛岃€屽叾涓?绡囨挙绋胯鏂囩殑鐞嗙敱鎭版伆灏辨槸鈥滃浘鐗囨搷绾碘€濓紙image manipulation锛?strong>[12]銆傜洰鍓嶈繕鏈夌害15绡囪鏂囨鍦ㄦ帴鍙楁湡鍒婇噸瀹★紝鍏朵腑鍖呮嫭鍙戣〃鍦ㄣ€婅嚜鐒堵烽仐浼犲銆嬶紙Nature Genetics锛夋湡鍒婄殑涓€绡囨枃绔狅紝浠ュ強鏂櫘鏋楁牸路鑷劧鏃椾笅銆婄檶鐥囧熀鍥犮€嬶紙Onceogene锛夌殑鍙︿竴绡囥€傘€婄瀛β蜂俊鍙蜂紶瀵笺€嬶紙Science Signalling锛夊垯鍦ㄨ皟鏌ヤ袱绡囪鏂囷紝灏卞凡缁忓畬鎴愮殑涓€绡囪鏂囧鏌ュ緢蹇細鍙戝竷涓€绡囧嫎璇0鏄庛€?/p>

鑰屽彟涓€鏈湡鍒娿€婄敓鐞嗗鏈熷垔銆嬶紙Journal of Physiology锛夎〃绀猴紝鍏堝墠宸茬粡閲嶆柊瀹℃煡杩囦袱绡囩浉鍏宠鏂囷紝涓嶈繃闈㈠杩戞湡鐨勬挙绋夸簨浠讹紝姝e湪鑰冭檻鏄惁鏇存敼鍏堝墠鐨勭珛鍦恒€傛湡鍒婂彂瑷€浜鸿〃绀哄湪绗竴娆¤皟鏌ヤ箣鍚庢湡鍒婂苟鏈噰鍙栦换浣曡鍔紝鍥犱负浠栦滑鏃犳硶鑾峰緱鍘熷鏁版嵁锛岃€屼笖鈥滃彂琛ㄥ湪鏈熷垔涓婄殑璁烘枃鍥剧墖娓呮櫚搴﹀疄鍐嶅お宸簡銆傗€?/p>

鐭ュ悕鐨勭鐮斿浘鐗囨墦鍋囧厛閿嬩汉鐗╀紛涓借帋鐧铰锋瘮鍏嬶紙Elisabeth Bik锛変篃鍙備笌浜嗚禌闂ㄦ墡鍚堜綔璁烘枃鐨勫浘鐗囨墦鍋囬槦浼嶃€傚ス琛ㄧず锛屼竴涓垚鍔熷疄楠屽20澶氬勾鏉ュ嚭鐜拌繖浜涙暟閲忕殑淇璁烘枃鐪嬩技涔熷悎鎯呭悎鐞嗭紝浣嗏€滅珶鐒舵湁5绡囪鏂囬兘鍥犱负鍥剧墖閫犲亣鑰屾挙绋匡紝杩欑‘瀹炶浜哄ぇ璺岀溂闀溿€傗€濅笉鍏嶈澶у鎷呭咖瀹為獙瀹ゆ槸鍚︿笉鍐嶇鎸佷弗璋ㄨ礋璐d汉鐨勭鐮旀€佸害锛岃€屾槸鑽夌巼澶勭悊瀹為獙鏁版嵁锛屽ぇ绗斾竴鎸ュ仛鍑烘紓浜浘鐗囧ソ灏藉揩鍙戣〃銆?/p>

鑰?鏈堢殑浜嬩欢鏇存槸灏嗚禌闂ㄦ墡閫佷笂浜嗘秹瀚屽鏈笉绔殑椋庡彛娴皷锛屼粬鎵€渚涜亴鐨勭害缈奥烽湇鏅噾鏂ぇ瀛﹂€氳繃鍙戣█浜鸿〃绀猴紝瀛︽牎鈥滃缁堢鎸侀拡瀵圭鐮斿噯纭€у拰绉戠爺璇氫俊鐨勯珮鏍囧噯銆佷弗瑕佹眰鈥濓紝骞朵細璁ょ湡搴斿浠讳綍绉戠爺涓嶇琛屼负鐨勬帶璇夛紝鈥滃闄㈡嫢鏈変弗鏍肩殑鏂规鍜岀▼搴忔潵瀹℃煡浠讳綍鐩稿叧鎸囨帶鈥濄€備絾鏄嫆缁濋€忛湶杩欎竴瀹℃煡杩囩▼鐨勫叿浣撶粏鑺傦紝涔熶笉鎰胯瘎璁洪拡瀵硅禌闂ㄦ墡浠ュ強鍥㈤槦鐨勫叿浣撴寚鎺с€?/p>

鍥剧墖閫犲亣涓庤鏂囨挙绋?/strong>

杩戝勾鏉ュ浘鐗囬€犲亣闂寮曞彂浜嗗悇澶ф湡鍒婄殑閲嶈銆傝櫧鐒舵瘡瀹舵湡鍒婂緢鏃╁氨鍙戣〃杩囨姇绋胯鏂囧浘鐗囧噯鍒欙紝浣嗗垽鏂浘鐗囬棶棰樼┒绔熸槸灞炰簬澶勭悊涓嶅綋锛岃繕鏄晠鎰忛€犲亣锛屼竴鐩存病鏈夐潪甯告槑纭殑绋嬪害鍒ゆ柇鏍囧噯銆傜洿鍒?021骞达紝鍑犲鍥介檯澶у瀷瀛︽湳鏈熷垔鑱斿悎璧锋潵[8]锛堝寘鎷埍鎬濆敮灏斻€佸▉绔嬨€佹柉鏅牸鏋椔疯嚜鐒剁瓑锛夛紝鍏卞悓鍒跺畾鍑虹鐮旇鏂囧浘鐗囬棶棰樼浉鍏崇殑鍒嗙骇鏍囧噯锛屼互鍙婁綔鑰呯殑鍥炲簲鍜岀紪杈戠殑搴斿鎺柦銆傚悓骞?鏈堝湪銆婂紑鏀剧瀛︽鏋躲€嬶紙OpenScienceFramework锛夐鍗版湰缃戠珯涓婂叕甯冧簡绗竴鐗堣崏妗?strong>[9]锛屽苟鍙婃椂鏇存柊锛屾棬鍦ㄥ敖蹇垚涓哄鐣屽叕璁ょ殑鏍囧噯锛屽叾涓皢鍥剧墖涓嶅綋澶勭悊闂鐢辫交鍒伴噸鍒嗕负涓変釜绛夌骇锛?/p>

绗竴绛夌骇锛屾寚鍥剧墖瀛樺湪涓嶅綋澶勭悊闂锛屼絾鎯呰妭杈冭交銆備緥濡傚浘鐗囬儴鍒嗗鍒躲€佹垨鑰呬笉鍚屽疄楠屾暟鎹悎骞剁瓑锛屽苟涓嶄細鏀瑰彉鐮旂┒缁撴灉鎴栭€犳垚璇銆備竴缁忓彂鐜帮紝鍙浣滆€呰兘澶熷強鏃舵彁渚涙簮鏁版嵁锛屽苟缁欏嚭鍚堢悊婊℃剰鐨勮В閲婏紝鏃犺鍙戣〃鍓嶅悗锛岀紪杈戦兘鍙繘琛屾洿姝c€佸嫎璇€?/p>

绗簩绛夌骇鍒欑浉瀵逛弗閲嶏紝鎸囧浘鐗囨暟鎹瓨鍦ㄦ槑鏄剧殑鈥滅編鍖栤€濈棔杩癸紝鎴栬€呮湭澹版槑鐨勫浘鐗?鏁版嵁鎿嶇旱锛屼粠鑰岀牬鍧忔暟鎹殑瀹㈣鍛堢幇鍜屽畬鏁存€э紝杩濊儗鍏鐨勫鏈疄璺佃鑼冿紝骞跺彲鑳戒細鏀瑰彉鍏抽敭鏁版嵁浠ュ強鎺ㄥ鍑虹殑缁撹銆傚湪鏈粡杩涗竴姝ヨ皟鏌ヤ箣鍓嶄笉鎺掗櫎鍒绘剰璇涔嬪珜銆傛鏃讹紝閫氳浣滆€呬笉浠呴渶瑕佹彁渚涚湡瀹炵殑婧愭暟鎹互鍙婂悎鐞嗘弧鎰忕殑瑙i噴锛岃繕瑕佸仛濂藉彲鑳芥挙绋跨殑蹇冪悊鍑嗗銆?/p>

鑰岀涓夌瓑绾у凡灞炰簬涓ラ噸鐨勫鏈笉绔涓猴細绡℃敼鍥剧墖鎴栬€呭浘鐗囬€犲亣锛屼富瑙備笂鏈夎瀵兼剰鍥撅紝鑰屼笖鍥剧墖鏁伴噺涓嶉檺浜庝竴寮狅紝鍏蜂綋鍒欏寘鎷湪鐪熷疄鐨勫浘鐗囧熀纭€涓婅繘琛屼汉涓轰慨鏀广€佸壀鍒囥€佹嫾鎺ュ唴瀹圭瓑鑰屾湭浜堟槑鏄炬爣绀猴紝鐮村潖浜嗗師濮嬫暟鎹殑瀹屾暣鎬х瓑銆備竴缁忓彂鐜帮紝濡傛灉浣滆€呮棤娉曠粰鍑哄悎鐞嗚В閲婃垨鑰呮簮鏁版嵁锛屽浜庡皻鏈彂琛ㄧ殑鏂囩珷锛岀紪杈戝彲鐩存帴鎷掔銆傝嫢鏂囩珷宸茬粡鍙戣〃锛屾湡鍒婂簲璇ョ洿鎺ヤ簣浠ユ挙绋夸綔涓烘儵鎴掋€?/p>

瀵逛簬杩欎竴鏂板嚭鐨勬爣鍑嗗拰鎺柦锛屽浘鐗囪瘹淇′笓瀹惰涓猴細鈥滆櫧鐒舵棤娉曞交搴曟潨缁濆浘鐗囬€犲亣闂锛屼絾浠嶇劧鎻愪緵浜嗘洿涓ユ牸鐨勫鏌ユ爣鍑嗭紝鐢ㄤ簬瑙勮寖鎶曠闃舵浠ュ強鍙戣〃涔嬪悗鐨勭鐮旇涓恒€傗€?strong>[8]

鏍规嵁鏍囧噯绛夌骇锛岃禌闂ㄦ墡鐨勫洓绡囨挙绋胯鏂囨樉鐒跺凡缁忓湪绗簩绛夌骇鍜岀涓夌瓑绾т箣闂粹€滄憞鎽嗏€濓紝鏃㈢劧浣滆€呮棤娉曡В閲婃竻妤氬浘鐗囧鍒剁殑鍏蜂綋鍘熷洜锛岄偅涔堜富鍔ㄦ挙绋垮彧鑳芥槸鍞竴鈥滀綋闈⑩€濈殑缁撴灉銆?/p>

閫氳浣滆€呰矗浠婚噸澶?/strong>

鍦ㄨ禌闂ㄦ墡鍚堣32绡囪閲嶆柊瀹℃煡鐨勮鏂囦腑锛?浠栨湰浜轰负閫氳浣滆€呮垨鍏卞悓閫氳浣滆€呮湁14绡囥€傛樉鐒讹紝杩欎簺璁烘枃杩樻秹鍙婂浣嶇煡鍚嶅鑰呫€傜幇鍦ㄨ繕涓嶆竻妤氳皝瀵瑰摢浜涙枃绔犱腑鐨勪换浣曢敊璇垨鑰呭浘鐗囬棶棰樺叿浣撹礋璐o紝涓嶅彲缃惁鐨勬槸锛屾棤璁鸿矗浠诲湪璋侊紝閫氳浣滆€呬綔涓洪噸瑕佺殑鎶婂叧浜猴紝蹇呴渶瑕佷繚璇佽鏂囨暣浣撶殑鐪熷疄鍙潬鎬с€?/p>

鍏虫敞瀛︽湳璇氫俊鐨勮鑰呭垪濂ュ凹寰仿锋柦鑰愬痉锛圠eonid Schneider锛夋浘浜?020骞村湪For Better Science缃戠珯涓婂彂琛ㄥ崥鏂囨寚鍑猴紝鍙楀埌璐ㄧ枒鐨勬枃绔犲綋涓湁璁稿浣滆€呴噸鍚堬紝鏆楃ず浠栦滑涔嬩腑鍙兘鏈変笉璐熻矗浠荤殑瀛︾敓鎴栧悎浣滆€咃紝浣嗏€滆禌闂ㄦ墡浣滀负璁稿鏂囩珷鐨勬湯浣嶄綔鑰呮垨閫氳浣滆€咃紝琛ㄦ槑浠栬礋鏈夋渶缁堣矗浠汇€傗€?strong>[13]

涓ゅ勾鍓嶏紝鍥藉唴涔熷叧娉ㄨ繃璧涢棬鎵庢秹瀚屽浘鐗囬€犲亣琛屼负鐨勬柊闂汇€傚浗鍐呬綆姘ч鍩熺爺绌跺鑰呭湪鎺ュ彈銆婁腑鍥界瀛︽姤銆嬮噰璁挎椂鎻愬嚭涓や釜浠や汉鎷呭咖鐨勬儏鍐碉紝鈥滅洰鍓嶈浜鸿川鐤戠殑澶氭暟鏄竴浜涘悜涓嬫父杞寲鐨勭爺绌躲€傗€?strong>[14]涓€鏂归潰浠栬偗瀹氫簡璧涢棬鎵庣殑璇哄宸ヤ綔闈炲父鎵庡疄锛岀粡杩囦簡鏃堕棿鐨勬楠岋紱浣嗗悓鏃朵篃鏆楃ず鍚庣画鐨勭爺绌舵湁鎬ュ姛杩戝埄涔嬪珜锛屾湭灏藉埌閫氳浣滆€呬箣璐c€傝濂栧緱涓诲皻涓斿姝わ紝閭d箞瀛︽湳涓嶇鐨勬儏鍐靛彲鑳芥洿鍔犳櫘閬嶃€?/p>

鍐典笖锛岄€氳浣滆€呬笉浠呭璁烘枃璐熻矗锛屾洿搴旇瀵瑰洟闃熶腑鐨勬瘡涓€浜鸿礋璐o紝瀛︽湳涓嶇鐨勫悗鏋滀簨瀹炰笂鐢辨暣涓棰樼粍鎵挎媴銆傚浜庡儚璧涢棬鎵庤繖鏍风殑椤跺皷绉戝瀹惰€岃█锛屼粎浠呮挙绋垮彲鑳戒笉浼氬浠栨湰浜轰骇鐢熷緢澶у奖鍝嶏紝浣嗗湪鍚屼竴璇鹃缁勫唴锛岃繕鏈変竴浜涜祫鍘嗗皻娴呫€佺敋鑷充笉鐭ユ儏鐨勫勾杞荤爺绌朵汉鍛橈紝浠栦滑浼氶潰涓存€庢牱鐨勫澧冨憿锛?strong>[15, 16]锛堝弬瑙併€婂甯堝鏈笉绔紝瀛︾敓灞ュ巻浼氭湁姹$偣鍚楋紵銆嬶級

浠栦滑鍙兘涓嶄細鍥犳秹瀚屽鏈笉绔€岃鎺ㄤ笂鑸嗚鐨勯鍙f氮灏栵紝浣嗘氮娼箣涓嬬殑浠栦滑涔熻窡鐫€閬畠銆備互缇庡浗涓轰緥锛屾牴鎹編鍥借瘹淇$爺绌跺姙鍏锛圤ffice of Research Integrity锛岀畝绉?ORI锛夌殑缁熻锛屾瘡骞?ORI 閽堝瀛︽湳涓嶇骞冲潎鏈?0 澶氳捣璋冩煡锛屽湪姣忎釜缁欏畾鐨勫勾浠斤紝閮藉彲鑳芥湁鍑犲崄鍚嶅勾杞荤爺绌朵汉鍛樺彂鐜拌嚜宸辩殑鐮旂┒椤圭洰闄峰叆鍗辨満锛屾垨鑰呭湪瀹為獙瀹ゅ叧闂悗涓嶅緱涓嶅寙蹇欏鎵炬柊鑱屼綅銆?/p>

浠栦滑鏈€澶х殑鎹熷け鍙兘鏄嚜宸辫緵鑻︿竴骞寸敋鑷冲骞寸殑鐮旂┒缁撴灉绐佺劧涔嬮棿鍏ㄩ儴浠樿涓滄祦锛屽悓鏃惰鑳岃礋瀛︽湳涓嶇鐨勫悕瑾夋崯澶便€備箣鍚庡湪瀵绘壘鏂拌亴浣嶇殑杩囩▼涓紝浠栦滑涔嬪墠鐨勮澶氬姫鍔涖€佷釜浜虹鐮旇兘鍔涘彲鑳芥棤娉曞睍绀猴紝灞ュ巻涓嚭鐜板按灏嵈鍙堥毦浠ュ惎榻跨殑鈥滅┖鐧芥湡鈥濄€傚嵆渚胯兘澶熻В閲婂綋鏃舵儏鍐碉紝浣嗚璇佹槑鑷繁锛屼笌鏂板洟闃熷缓绔嬩俊浠诲叧绯伙紝鈥滃鏈笉绔€濅粛鏄渶澶ч殰纰嶃€?/p>

鍙︿竴鏂归潰锛屽績鐞嗗眰闈㈠彈鍒扮殑褰卞搷鏄渶鐩存帴鐨勶紝涓嶄粎璁╁勾杞荤鐮斾汉鍛樺涓汉瀛︽湳鍚嶅0鍜岃亴涓氬墠閫旂劍铏戯紝鏇村鏄撳瀛︽湳鍚堜綔鐢氳嚦鏁翠釜绉戝鐣屼骇鐢熶俊浠诲嵄鏈猴紝杩欑宸ㄥぇ鐨勫績鐞嗗垱浼ゅ彲鑳藉洜姝よ浠栦滑褰诲簳鏀惧純瀛︽湳浜嬩笟銆傚綋鐒讹紝涔熸湁涓€浜涘唴蹇冨己澶х殑瀛﹁€咃紝浠栦滑浼氬洜涓鸿繖娈电粡鍘嗛噸鏂板瑙嗙瀛︾爺绌讹紝浠ユ洿涓ヨ皑鐨勬€佸害杩涜宸ヤ綔锛岃繖鏄汉浠笇鏈涜鍒扮殑缁撴灉銆?/p>

鎬昏€岃█涔嬶紝绉戝姹傜湡姹傚疄锛屽寘鎷浘鐗囬€犲亣鍦ㄥ唴鐨勪笉绔涓鸿缁濆鎶靛埗銆備笉瀹岀編鐨勫浘鐗囧苟涓嶅彲鎬曪紝鍙€曠殑鏄笉鍔犵害鏉熺殑閫犲亣琛屼负锛岀粰绉戠爺浜哄憳鍒蜂笂闅句互娲楀幓鐨勬薄鐐癸紝璁╃瀛︿抚澶辩湡瀹炪€佽瘹淇★紝璐诲鏃犵┓銆?/p>

鍙傝€冭祫鏂?/strong>

https://www.pnas.org/doi/full/10.1073/pnas.2213288119

https://www.pnas.org/doi/full/10.1073/pnas.2213287119

https://www.pnas.org/doi/full/10.1073/pnas.2213285119

https://www.pnas.org/doi/full/10.1073/pnas.2213289119

https://www.biorxiv.org/content/10.1101/2022.07.11.499380v1

https://www.biorxiv.org/content/10.1101/2022.06.15.492526v1

https://www.biorxiv.org/content/10.1101/2022.06.27.497729v1

https://www.nature.com/articles/d41586-021-02610-7

https://osf.io/kgyc6

https://portlandpress.com/biochemj/article/434/3/571/80024/Activation-of-hypoxia-inducible-factor-1-in-human

https://www.pubpeer.com/search?q=gregg+semenza

https://www.nature.com/articles/d41586-022-03032-9

鍑哄搧锛氱鏅腑鍥?/p>

关键词:璇哄,,寰椾,富娣遍,櫡璁,烘枃,鍥剧,墖閫,
>>>
>>>
频道热点
生活
预防
保健
科普
  • 8000家咖啡馆创造“全球第一”,上海的咖啡文化为什么吸引人?
  • “咖啡之城”的味道,以及M恋
  • 鍥藉鍗仴濮旓細楂樿鍘嬫爣鍑嗕笉鍙橈紒涓撳瑙h130/80mmHg浜夎
  • 鏂板啝鍜屾祦鎰熸湁浠€涔堝尯鍒紵骞磋交浜哄簲璇ュ洡浠€涔堬紵6涓叧
  • 50岁后是养寿关键期,还真需要防3病,一文参考下
  • 如果活到一百岁,应该怎么做?一文学习下
  • 2022涓栫晫鏉啝鍐涙槸宸磋タ闃燂紵杩欐鏄疉I璇寸殑
  • 寮犵泭鍞愶細鏁板澶╂墠鍜屼粬瀛ょ嫭鐨勪簩鍗佸勾
  • 网站地图 | 长发地图 | 用户登录 | 忘记密码 | 投稿邮箱:2012648158@qq.com
    管理员QQ:2012648158 赣ICP备18014991号