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Colosal 鍏徃璁″垝鍦ㄤ縿缃楁柉鍖楅儴寤虹珛涓€涓?strong>鏇存柊涓栧叕鍥?/strong>锛岀敤鏉ラ噴鏀捐繖浜涘娲荤殑鐚涚姼璞★紝杩欏惉璧锋潵寰堝儚渚忕綏绾叕鍥?/strong>锛屽崠绁ㄨ浜轰滑鍙傝涓€绉嶅凡浜庝笂涓囧勾鍓嶇伃缁濈殑搴炵劧澶х墿浼间箮涓€涓專閽辩殑濂界敓鎰忋€備絾 Colosal 鍏徃浼间箮骞朵笉鎵撶畻杩欎箞骞诧紝浠栦滑鐨勮鎯虫槸锛岃繖浜涚寷鐘歌薄浼氭帹鍊掕繖閲屾爲鏈紝韪╄笍绉洩锛屾仮澶嶈崏鍘燂紝甯姪缁存寔杩欎簺鍐诲湡鍦板甫鐨勫喕缁撶姸鎬侊紝浠庤€屽噺灏戜簩姘у寲纰冲拰鐢茬兎绛夋俯瀹ゆ皵浣撶殑閲婃斁锛屽噺缂撴皵鍊欏彉鏆栥€傜洰鍓嶏紝瀹冧滑鐨勭爺绌朵汉鍛樻璁″垝鍦ㄨ繖閲屾祴璇曞啀閲庡寲瀵圭敓鎬佸拰姘斿€欏奖鍝嶇殑鐞嗚銆?/p> 澶嶆椿娓℃浮楦?/p> 
鍦ㄨ繃鍘?0骞翠腑锛屽叏鐞冮笩绫绘暟閲忓凡缁忓噺灏戜簡30浜垮鍙紝鏈?00澶氱楦熺被宸茬伃缁濄€侀噹澶栫伃缁濇垨鏋佸害婵掑嵄銆侰olosal 鍏徃涔嬫墍浠ラ€夋嫨鍘诲娲?strong>娓℃浮楦?/strong>锛屾槸鍥犱负娓℃浮楦熸槸涓€涓汉绫诲鑷寸墿绉嶇伃缁濈殑鏍囧織鎬ф渚嬶紝17涓栫邯鏅氭湡锛岃繖绉嶄綋鍨嬪法澶с€佷笉浼氶鐨勯笩绫讳粠姣涢噷姹傛柉宀涚伃缁濓紝姝ゆ椂璺濈瀹冧滑琚彂鐜颁粎浠?00澶氬勾銆傛浮娓￠笩涔熸垚涓轰簡绗竴涓璁板綍鐨勫洜浜虹被娲诲姩鑰屽鑷寸伃缁濈殑鐗╃銆?/p>
Colossal聽鍏徃澶嶆椿娓℃浮楦?/strong>锛圧aphus cucullatus锛夌殑璁″垝灏嗕粠瀹冪幇瀛樼殑浜茬紭鍏崇郴鏈€杩戠殑缁胯搼楦?/strong>锛圕aloenas nicobarica锛夊紑濮嬶紝浠栦滑璁″垝浠庣豢钃戦笭涓垎绂诲拰鍩瑰吇鍘熷鐢熸畺缁嗚優锛圥GC锛夛紝鐒跺悗浣跨敤CRISPR鍩哄洜缂栬緫宸ュ叿缂栬緫PGC锛屼娇鍏朵笌娓℃浮楦熺殑DNA搴忓垪鐩稿尮閰嶃€傜劧鍚庯紝灏嗚繖浜涚粡杩囧熀鍥犵紪杈戠殑PGC妞嶅叆浠ｅ瓡楦熺被鐨勮儦鑳庝腑锛屼互浜х敓宓屽悎浣撱€傝繖浜涘叿鏈夋浮娓￠笩鍜岀豢钃戦笭涓や釜鐗╃鐨凞NA鐨勫祵鍚堜綋锛岃兘澶熶骇鐢熺被浼兼浮娓￠笩鐨勫嵉瀛愬拰绮惧瓙锛屽彲鑳借繘涓€姝ュ鍖栧嚭绫讳技娓℃浮楦熺殑楦熺被銆?/p> 澶嶆椿娓℃浮楦熺殑椤圭洰闈复鐨勬渶澶ф寫鎴樻槸纭畾灏嗙豢钃戦笭杞彉涓烘浮娓￠笩鎵€闇€鏀瑰彉鐨勫熀鍥狅紝鍔犲窞澶у鍦ｅ厠椴佸吂鍒嗘牎鍙ら仐浼犲瀹?strong>Beth Shapiro 
鐒惰€岋紝鐜板瓨鐨勬浮娓￠笩鏍囨湰閮戒繚瀛樺湪鐑甫鍦板尯锛岃繖瀵艰嚧鍏跺緢闅捐幏鍙栧儚淇濆瓨鍦ㄦ案涔呭喕鍦熷眰鐨勭寷鐘歌薄閭ｆ牱鐨勫畬鏁村熀鍥犵粍锛屾祴搴忓緱鍒扮殑娓℃浮楦熷熀鍥犵粍鍙兘瀛樺湪鐫€缂哄彛鍜岄敊璇€傛澶栵紝鍗充娇鎵惧埌浜嗘浮娓￠笩涓庣豢钃戦笭涔嬮棿鍏ㄩ儴宸紓鍩哄洜锛屽皢鎵嶅彲鑳藉瓨鍦ㄧ殑鎴愬崈涓婁竾绉嶅熀鍥犲樊寮傚紩鍏GC涓紝鏄剧劧骞朵笉瀹规槗銆傚嵆浣胯繖浜涢兘鍋氬埌浜嗭紝缁忚繃澶ч噺鍩哄洜缂栬緫鐨凱GC妞嶅叆浠ｅ瓡楦熺被鑳氳儙骞惰鍏朵骇鐢熺簿瀛愬拰鍗靛瓙鍚屾牱鍏呮弧鎸戞垬銆傜洰鍓嶇瀛﹀宸茬粡鍒涢€犲嚭浜嗗彲浠ヤ骇鐢熼箤楣戠簿瀛愮殑宓屽悎楦¤儦鑳庯紝浣嗚繕涓嶈兘浜х敓鍗靛瓙銆傛渶鍚庯紝娓℃浮楦熺殑浣撳瀷姣旂豢钃戦笭澶у緱澶氾紝鏄剧劧鏃犳硶鍦ㄧ豢钃戦笭涓鍖栨浮娓￠笩锛岃繕闇€瑕佹壘鍒颁竴绉嶄綋鍨嬬被浼肩殑楦熺被浠ｅ瓡銆?/p>
澶嶆椿琚嬬嫾
琚嬬嫾锛屼篃鍙鏂┈灏间簹铏庯紝鏄竴绉嶅ぇ鍨嬮鑲夋湁琚嬪姩鐗╋紝鍥犺娆ф床娈栨皯鑰呭ぇ閲忔崟鏉€鑰屽揩閫熺伃缁濓紝1936骞达紝鏈€鍚庝竴鍙鐙煎湪鍔ㄧ墿鍥浜°€傜敱浜庣伃缁濇椂闂磋緝杩戯紝琚嬬嫾鏈夌潃淇濆瓨瀹屽ソ鐨勮儦鑳庡拰鏍囨湰锛岃繖缁欏娲昏鐙煎瀹氫簡鍩虹銆?/p>
Colossal聽鍏徃澶嶆椿琚嬬嫾鐨勮鍒掔敱钁楀悕琚嬬嫾鐮旂┒涓撳銆佸ⅷ灏旀湰澶у鐨?strong>Andrew Pask鏁欐巿棰嗚锛屽啀杩囧幓20骞撮噷锛屼粬鐨勫洟闃熶竴鐩磋嚧鍔涗簬瀵硅鐙艰繘琛屽熀鍥犵粍娴嬪簭銆?strong>琚嬮棘绉?/strong>锛圖asyuridae锛夋槸琚嬬嫾鐨勮繎浜诧紝瀹冧滑鍦ㄨ繘鍖栦笂涓庤鐙兼湁7000涓囧勾鐨勫樊寮傘€傜爺绌跺洟闃熷笇鏈涘埄鐢–RISPR鍩哄洜缂栬緫鎶€鏈皢琚嬬嫾鍩哄洜鎻掑叆琚嬮棘绉戝姩鐗╁熀鍥犵粍涓紝鐒跺悗灏嗙紪杈戠殑缁嗚優鏍哥Щ妞嶅埌琚嬮棘绉戝姩鐗╁嵉瀛愪腑锛屽垱寤鸿鐙艰儦鑳庯紝閫氳繃浠ｅ瓡鍔ㄧ墿鐢熶笅琚嬬嫾銆?/p>
鍒涢€犱竴涓洿缇庡ソ鐨勪笘鐣?/p>
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鍙傝€冭祫鏂?/strong>锛?/p> 1.聽https://www.nature.com/articles/ncomms15112/ 2. https://www.nature.com/articles/s41586-021-03416-3 https://colossal.com/ https://www.nature.com/articles/d41586-023-00379-5https://colossal.com/
